Despite extensive reading of literature and resultant hair loss, there is no inspiration for selecting thesis topics. However, research in the life sciences commonly has an intimate association with our life, and perhaps we can conduct research from the perspective of “balding head”.

Hair loss can happen in any position of the body, which occurring in scalp is called alopecia. Although alopecia barely affects the health of the human body, it greatly impacts psychology and career choice, and also may be a sign of systemic diseases. Then, what are the design ideas about alopecia? Let’s have a discussion.

Here is a paper titled “Bioinspired engineering ADSC nanovesicles thermosensitive hydrogel enhance autophagy of dermal papilla cells for androgenetic alopecia treatment”, published in Bioactive Materials with an IF of 18.9. Hoping this paper can bring you different inspiration!

1. Research background

(1) Stem cell-derived exosomes have abilities to transport various biological components and are widely utilized in tissue repair.

(2) The exorbitant expense and fewer yields associated with exosome isolation are greatly challenging to exosome therapies that await immediate resolution.

(3) Cell-derived nanovesicles (CNVs) have a low production cost, and can generate more materials that can enhance the potential of hair regeneration in androgenic alopecia (AGA).

(4) What is the potential of ADSC-NVs to improve the efficacy of hair regeneration in AGA?

(5) Engineered CNVs may serve as a potential novel therapeutic route to achieve efficient hair regeneration in AGA.

2.Technical route

3. Research results

(1) Construction and characterization of CNVs: DPCs can internalize ADSC-NVs and HSF-NVs.

(2) The impact of ADSC-NVs on hair regeneration in AGA mice: ADSC-NVs can reverse the delay in the HF growth cycle induced by DHT.

(3) ADSC-NVs exerts a protective effect on DHT-injured and macrophage-injured DPCs.

(4) JAM-A proteins play a central role in ADSC-NVs-mediated hair regeneration in AGA.

(5) Characterization of JAM-A@NV-enriched thermosensitive sustained-release platform: the development of JAM-A@NV-enriched thermosensitive sustained-release platform is effective.

(6) JAM-A^OE@NV has protective effects in vivo and in vitro.